Community-associated Methicillin-resistant Staphylococcus aureus, Colombia

transmission of methicillin-resistant Staphylococcus aureus between domestic pets and humans in veterinary clinics and in the household. To the Editor: Methicillin-resistant Staphylococcus aureus (MRSA) is an established nosocomial pathogen worldwide but more recently has emerged as a highly virulent organism in the community, particularly in the United States (1–3). In Latin America, community-associated MRSA (CA-MRSA) has only been described in the southern area of the continent (Uruguay and Brazil) (4,5). No reports from the Andean region are available. We describe 2 cases of CA-MRSA causing soft-tissue infections (1 severe) in Colombia. The first case was in a 19-year-old man with a history of trauma to the left side of his body 1 week before admission after a fall. On admission, he complained of 2 days of fever, malaise, erythema and induration in the left hemithorax extending to the left thigh, and purulent secretion from an excoriation on the anterior aspect of the left thigh. He had no previous medical history. No previous hospitalizations or antimicrobial drug prescriptions were documented, nor did he report relatives with history of recent hospitalizations. Vital signs at admission were normal except for fever (39°C), and physical examination showed induration and erythema in the region of left hemithorax extending to the thigh, with an area of excoriation in the same thigh with purulent discharge. Laboratory evaluation showed a leukocyte count of 23.1×10 9 /L (86% neutrophils with 2% band forms) and elevated C-reactive protein levels. The patient was hospitalized. Because necrotizing fascitis was suspected , intravenous ampicillin-sul-bactam (12 g per day) was started, and surgical evaluation was requested. The patient underwent surgical debridement of the left thigh, left hemiabdomen, and hemithorax, which confirmed the diagnosis of necrotizing fascitis. Intravenous van-comycin (1 g every 12 h) was added to the regimen, and the patient was transferred to the intensive care unit. After several surgical debridements, the patient underwent placement of cutaneous-muscle grafts. He was discharged from the hospital without complications after completing 14 days of antimicrobial agents. The second case involved a 53-year-old man with no history of previous hospitalizations who reported to the emergency department with a 3-day history of fever, pain, swelling, and warm sensation on the posterior aspect of the left thigh. A diagnosis of cellulitis was made, and cephalexin (500 mg every 6 h) and gentamicin (160 mg intramuscularly every 24 h) were administered for 7 days without improvement. He returned to the …